Another interesting article about NGAL as a marker for AKI,  from the University of Liege

NGAL biomarqueur de lésion rénale

Docteur at Hospital du Nord in Saint Etienne France  Amandine Gagneux-Brunon and Belgian Docteurs at the University of Liege , Pierre Delanaye, Delphine LeGrand, Etienne Cavalier and Christophe Mariat have made an interesting article about the potential of NGAL (as usual) . They adress the problem of a the various Thresholds (Cutoffs)

The conclusion however is this: At present, the analytical performance of the commercially kits is better and more precise in urine than in blood. (my comment – Read and weep Alere)  It might be wise to  integrate  these assays in clinical algorithms (or use them  in combination with other biomarkers of acute renal damage)  to increase the diagnostic performance. The real question is whether it NGAL provides added value compared to simple  or less expensive traditional markers such as serum creatinine (or even cystatin C) But –  Further studies are needed…

I have only the french transcript – and my french is a bit rusty – so it will take some time for me to digest it (my medical french is even more rusty than my everyday vocabulary) – but take a look at it yourself: The article

About Stengaard

BioPorto investor from way back when... I've invested in BioPorto ever since they made their debut on the danish stock exchange, it been a looooong journey with many obstacles. But well worth it all if Bioporto maintains their patent after the proceedings in 2014, and enters into agreements with Global Distributors in 2012 and 2013 If not, then it'll take another xx.years :)

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One Response to NGAL, biomarker of acute kidney injury

  1. stengaard says:

    an interesting quote: Large multicenter studies to further define the predictive role of plasma and urine NGAL as a member of the putative AKI panel have been initiated, robust assays for commercialization are nearly complete, and the results are awaited with optimism.

    from : http://www.academypublish.org/papers/pdf

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