As mentioned in the MedicoInvestor Presentation NGAL for Dummies, Inflammation and cancer will often result in higher NGAL values, than what is present in normal healthy individuals. NGAL is not exclusively produced by the Kidneys, but also from whote blood cells, and other types of tissue.

This Chinese survey demonstrates that higher values than normal are seen in cancerpatients.

Other studies have shown that healthy individuals (the upper quartile) have NGAL values up to 146 ng/ml.

So what does that mean ? Well – for a start, if you use a cutoff of 150 ng/ml as suggested by Alere (and mentioned as a possible threshold by  Abbott) –  you will label a lot of false positive patients as AKI patients

The abovementiond study support this

In another interesting study NGAL has another mores sinister role to play…

 

About Stengaard

BioPorto investor from way back when... I've invested in BioPorto ever since they made their debut on the danish stock exchange, it been a looooong journey with many obstacles. But well worth it all if Bioporto maintains their patent after the proceedings in 2014, and enters into agreements with Global Distributors in 2012 and 2013 If not, then it'll take another xx.years :)

 

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