NGAL, biomarker of acute kidney injury

By On 31. May 2012 · 1 Comment · In BioPorto

Another interesting article about NGAL as a marker for AKI,  from the University of Liege

NGAL biomarqueur de lésion rénale

Docteur at Hospital du Nord in Saint Etienne France  Amandine Gagneux-Brunon and Belgian Docteurs at the University of Liege , Pierre Delanaye, Delphine LeGrand, Etienne Cavalier and Christophe Mariat have made an interesting article about the potential of NGAL (as usual) . They adress the problem of a the various Thresholds (Cutoffs)

The conclusion however is this: At present, the analytical performance of the commercially kits is better and more precise in urine than in blood. (my comment – Read and weep Alere)  It might be wise to  integrate  these assays in clinical algorithms (or use them  in combination with other biomarkers of acute renal damage)  to increase the diagnostic performance. The real question is whether it NGAL provides added value compared to simple  or less expensive traditional markers such as serum creatinine (or even cystatin C) But –  Further studies are needed…

I have only the french transcript – and my french is a bit rusty – so it will take some time for me to digest it (my medical french is even more rusty than my everyday vocabulary) – but take a look at it yourself: The article

About Stengaard

BioPorto investor from way back when... I've invested in BioPorto ever since they made their debut on the danish stock exchange, it been a looooong journey with many obstacles. But well worth it all if Bioporto maintains their patent after the proceedings in 2014, and enters into agreements with Global Distributors in 2012 and 2013 If not, then it'll take another xx.years 🙂

Related posts:

  1. Blast injury / Shotgun injury – and NGAL Summer of 2011 brought – amongst record rains and rare...
  2. Is NGAL the Troponin of the kidney? An article in Clinical Laboratory Online, written by Dr. Marlies Ostermann and...
  3. NGAL as a marker of Acute Heart Failure (AHF) “Prognostic utility of plasma neutrophil gelatinase-associated lipocalin in patients with...
  4. NGAL and Acute Heart Failure (AHF) According to an article in the European Journal of Heart...
  5. Abbott ARCHITECT VS. BioSite Triage. In the 2. edition of Clinical and Laboratory Medicine Vol....
Tagged with: • • • •
 

One Response to NGAL, biomarker of acute kidney injury

  1. stengaard says:
    31. May 2012 at 11:32

    an interesting quote: Large multicenter studies to further define the predictive role of plasma and urine NGAL as a member of the putative AKI panel have been initiated, robust assays for commercialization are nearly complete, and the results are awaited with optimism.

    from : http://www.academypublish.org/papers/pdf…

    Reply

Leave a Reply

Your email address will not be published. Required fields are marked *

Set your Twitter account name in your settings to use the TwitterBar Section.